Yes, Little Pony has video games.
The Road Warriors from several WWE games appear in Mat Mania.
Mat Mania has cameos of Darth Vader and Princess Leia.
Darth Vader, Yoda, and Starkiller appear in Soul Calibur IV.
Kratos appears in a Soul game and in Playstation All-Stars alongside Bioshock’s Big Daddy.
A Big Daddy can be found in a Borderlands DLC.
In the credits, Borderlands production team member Chris Francis gives thanks to “his adorable Fluttershy” from My Little Pony.